Protein critical for insulin secretion may be contributor to diabetes
A cellular protein from a family involved in several human diseases is crucial for the proper production and release of insulin, new research has found, suggesting that the protein might play a role in...
View ArticleWorm genes KO'd
Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for...
View ArticleGene knockout makes female mice masculine
The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them,...
View ArticleMuscle gene may provide new treatments for obesity and diabetes
(PhysOrg.com) -- Skeletal muscle enables us to walk, run or play a musical instrument, but it also plays a crucial role in controlling disease. Rockefeller University scientists have now shown how a...
View ArticleDeleting ghrelin receptor, but not ghrelin, turns up fat-burning thermostat
Deleting the receptor, not the protein ghrelin itself, turns up the body's fat-burning thermostat, giving aging mice an exothermic boost toward a svelte physique, researchers reported at the American...
View ArticleNew insights into insulin resistance could lead to better drugs for diabetics
Research published in the October Molecular and Cellular Biology moves us closer to developing drugs that could mitigate diabetes.
View ArticleOne of the enzymes known to regulate the cell cycle has now been shown to...
Cyclin-dependent kinase 1 (Cdk1) is a member of the Cdk family of enzymes which control the cell cycle. Philipp Kaldis at the A*STAR Institute of Molecular and Cell Biology and co-workers have now...
View ArticleFast track to mouse modeling
What genes are responsible for the development of breast cancer? What are the brain cell mutations that lead to the onset of Alzheimer's? To find new therapies, scientists have to understand how...
View ArticleMouse experiments suggest that a noncoding RNA can be vital for successful...
The proteins that underlie nearly all biological mechanisms are produced from RNA molecules transcribed from genetic sequences in DNA. However, a large proportion of transcribed RNA is not transcoded...
View ArticleHighly efficient CRISPR knock-in in mouse
Genome editing using CRISPR/Cas system has enabled direct modification of the mouse genome in fertilized mouse eggs, leading to rapid, convenient, and efficient one-step production of knockout mice...
View ArticleFaster, more efficient CRISPR editing in mice
University of California, Berkeley scientists have developed a quicker and more efficient method to alter the genes of mice with CRISPR-Cas9, simplifying a procedure growing in popularity because of...
View ArticleResearchers identify gene for adapting to changing seasons
University of Toronto researchers have identified a gene that determines whether the body will adapt to changing seasons.
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